Human beta-defensin 3 is up-regulated in cutaneous leprosy type 1 reactions.

• Main Authors: Anna L Cogen (Author), Stephen L Walker (Author), Chrissy H Roberts (Author), Deanna A Hagge (Author), Kapil D Neupane (Author), Saraswoti Khadge (Author), Diana N J Lockwood (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2012-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BACKGROUND:Leprosy, a chronic granulomatous disease affecting the skin and nerves, is caused by Mycobacterium leprae (M. leprae). The type of leprosy developed depends upon the host immune response. Type 1 reactions (T1Rs), that complicate borderline and lepromatous leprosy, are due to an increase i...