EIF4A3-induced Circ_0001187 facilitates AML suppression through promoting ubiquitin-proteasomal degradation of METTL3 and decreasing m6A modification level mediated by miR-499a-5p/RNF113A pathway

• Main Authors: Xinyu Yang (Author), Fengjiao Han (Author), Xiang Hu (Author), Guosheng Li (Author), Hanyang Wu (Author), Can Can (Author), Yihong Wei (Author), Jinting Liu (Author), Ruiqing Wang (Author), Wenbo Jia (Author), Chunyan ji (Author), Daoxin Ma (Author)
• Format: Book
• Published: BMC, 2023-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Aberrant expression of circRNAs has been proven to play a crucial role in the progression of acute myeloid leukemia (AML); however, its regulatory mechanism remains unclear. Herein, we identified a novel circRNA, Circ_0001187, which is downregulated in AML patients, and its low level contri...