Inhibition of IL-1 Signaling by Antisense Oligonucleotide-mediated Exon Skipping of IL-1 Receptor Accessory Protein (IL-1RAcP)

• Main Authors: A Seda Yılmaz-Eliş (Author), Annemieke Aartsma-Rus (Author), Peter AC 't Hoen (Author), Huma Safdar (Author), Cor Breukel (Author), Bart JM van Vlijmen (Author), Judith van Deutekom (Author), Sjef de Kimpe (Author), Gert-Jan van Ommen (Author), J Sjef Verbeek (Author)
• Format: Book
• Published: Elsevier, 2013-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The cytokine interleukin 1(IL-1) initiates a wide range of proinflammatory cascades and its inhibition has been shown to decrease inflammation in a variety of diseases. IL-1 receptor accessory protein (IL-1RAcP) is an indispensible part of the IL-1R complex that stabilizes IL-1/IL-1R interaction and...