Pharmacokinetic and pharmacodynamic modeling of oral mitiglinide on glucose lowering in healthy Chinese volunteers

• Main Authors: Shijia Liu (Author), Peidong Chen (Author), Yang Zhao (Author), Guoliang Dai (Author), Bingting Sun (Author), Yao Wang (Author), Anwei Ding (Author), Wenzheng Ju (Author)
• Format: Book
• Published: BMC, 2017-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Mitiglinide is a widely used agent for diabetic treatment. We established a pharmacokinetic-pharmacodynamic (PK-PD) model to illustrate the relationship between mitiglinide plasma concentration and its glucose lowering effects in healthy volunteers. Methods The volunteers partici...