Tetrafunctional Block Copolymers Promote Lung Gene Transfer in Newborn Piglets

• Main Authors: Ignacio Caballero (Author), Mickaël Riou (Author), Océane Hacquin (Author), Claire Chevaleyre (Author), Céline Barc (Author), Jérémy Pezant (Author), Anne Pinard (Author), Julien Fassy (Author), Roger Rezzonico (Author), Bernard Mari (Author), Nathalie Heuzé-Vourc'h (Author), Bruno Pitard (Author), Georges Vassaux (Author)
• Format: Book
• Published: Elsevier, 2019-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Tetrafunctional block copolymers are molecules capable of complexing DNA. Although ineffective in vitro, studies in mice have shown that the tetrafunctional block copolymer 704 is a more efficient lung gene transfer agent than the cationic liposome GL67A, previously used in a phase II clinical trial...