Processing Impact on Performance of Solid Dispersions

• Main Authors: Dan Zhang (Author), Yung-Chi Lee (Author), Zaher Shabani (Author), Celeste Frankenfeld Lamm (Author), Wei Zhu (Author), Yongjun Li (Author), Allen Templeton (Author)
• Format: Book
• Published: MDPI AG, 2018-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The development of a weakly basic compound is often challenging due to changes in pH that the drug experiences throughout the gastrointestinal tract. As the drug transitions from the low pH of the stomach to the higher pH of the small intestine, drug solubility decreases. A stomach with a higher pH,...