Development and pharmacokinetic assessment of a fully canine anti-PD-1 monoclonal antibody for comparative translational research in dogs with spontaneous tumors

• Main Authors: Sho Yoshimoto (Author), Nicholas Chester (Author), Ailian Xiong (Author), Enrico Radaelli (Author), Hong Wang (Author), Marc Brillantes (Author), Gayathri Gulendran (Author), Patrick Glassman (Author), Don L. Siegel (Author), Nicola J. Mason (Author)
• Format: Book
• Published: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

ABSTRACTPD-1 checkpoint inhibitors have revolutionized the treatment of patients with different cancer histologies including melanoma, renal cell carcinoma, and non-small cell lung carcinoma. However, only a subset of patients show a dramatic clinical response to treatment. Despite intense biomarker...