Suberoylanilide Hydroxamic Acid Attenuates Autoimmune Arthritis by Suppressing Th17 Cells through NR1D1 Inhibition

• Main Authors: Da Som Kim (Author), Hong-Ki Min (Author), Eun Kyung Kim (Author), Seung Cheon Yang (Author), Hyun Sik Na (Author), Seon-Yeong Lee (Author), Jeong-Won Choi (Author), Kyung-Ah Jung (Author), Seung-Ki Kwok (Author), Sung-Hwan Park (Author), Mi-La Cho (Author)
• Format: Book
• Published: Hindawi Limited, 2019-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Rheumatoid arthritis (RA) is a type of systemic autoimmune arthritis that causes joint inflammation and destruction. One of the pathological mechanisms of RA is known to involve histone acetylation. Although the histone deacetylase (HDAC) inhibitor suberoylanilide hydroxamic acid (SAHA) can attenuat...