A delta opioid receptor agonist, KNT-127, in the prelimbic medial prefrontal cortex attenuates glial glutamate transporter blocker-induced anxiety-like behavior in mice

• Main Authors: Akiyoshi Saitoh (Author), Akinobu Soda (Author), Shuhei Kayashima (Author), Kazumi Yoshizawa (Author), Jun-Ichiro Oka (Author), Hiroshi Nagase (Author), Mitsuhiko Yamada (Author)
• Format: Book
• Published: Elsevier, 2018-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We previously reported that systemic administration of a delta opioid receptor (DOP) agonist, KNT-127, produced a potent anxiolytic-like effect in rats. Interestingly, DOPs are highly distributed in the prelimbic medial prefrontal cortex (PL-PFC). In the present study, we investigated the effect of...