Physiologically‐Based Pharmacokinetic Modeling Approach to Predict Rifampin‐Mediated Intestinal P‐Glycoprotein Induction

Physiologically‐Based Pharmacokinetic Modeling Approach to Predict Rifampin‐Mediated Intestinal P‐Glycoprotein Induction

Physiologically‐based pharmacokinetic (PBPK) modeling is a powerful tool to quantitatively describe drug disposition profiles in vivo, thereby providing an alternative to predict drug-drug interactions (DDIs) that have not been tested clinically. This study aimed to predict effects of rifampin‐media...

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Main Authors: Shinji Yamazaki (Author), Chester Costales (Author), Sarah Lazzaro (Author), Soraya Eatemadpour (Author), Emi Kimoto (Author), Manthena V. Varma (Author)
Format: Book
Published: Wiley, 2019-09-01T00:00:00Z.
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