Seed- and Soil-Dependent Differences in Murine Breast Tumor Microenvironments Dictate Anti-PD-L1 IgG Delivery and Therapeutic Efficacy

• Главные авторы: Yan Ting Liu (Автор), Shreya Goel (Автор), Megumi Kai (Автор), Jose Alberto Moran Guerrero (Автор), Thao Nguyen (Автор), Junhua Mai (Автор), Haifa Shen (Автор), Arturas Ziemys (Автор), Kenji Yokoi (Автор)
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• Опубликовано: MDPI AG, 2021-04-01T00:00:00Z.
• Предметы: article
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We sought to determine if Stephen Paget's "seed and soil" hypothesis of organ-preference patterns of cancer metastasis can explain the development of heterogeneity in a tumor microenvironment (TME) as well as immunotherapeutic delivery and efficacy. We established single-cell-derived...