Seed- and Soil-Dependent Differences in Murine Breast Tumor Microenvironments Dictate Anti-PD-L1 IgG Delivery and Therapeutic Efficacy

• Glavni autori: Yan Ting Liu (Autor), Shreya Goel (Autor), Megumi Kai (Autor), Jose Alberto Moran Guerrero (Autor), Thao Nguyen (Autor), Junhua Mai (Autor), Haifa Shen (Autor), Arturas Ziemys (Autor), Kenji Yokoi (Autor)
• Format: Knjiga
• Izdano: MDPI AG, 2021-04-01T00:00:00Z.
• Teme: article
• Online pristup: Connect to this object online.

We sought to determine if Stephen Paget's "seed and soil" hypothesis of organ-preference patterns of cancer metastasis can explain the development of heterogeneity in a tumor microenvironment (TME) as well as immunotherapeutic delivery and efficacy. We established single-cell-derived...