Age-Related Modifications in Circulating IL-15 Levels in Humans

• Main Authors: Sebastiano Gangemi (Author), Giorgio Basile (Author), Daniela Monti (Author), Rosaria Alba Merendino (Author), Giuseppe Di Pasquale (Author), Ursula Bisignano (Author), Vittorio Nicita-Mauro (Author), Claudio Franceschi (Author)
• Format: Book
• Published: Hindawi Limited, 2005-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Aging is associated to a progressive establishing of a chronic inflammatory state linked to a continuous long exposure to antigens. Since IL-15 stimulates the proliferation of memory T cells and the immunosenescence is characterized by accumulation of memory T cells and exhaustion of naive T cells,...