Exploring the Fate of Antibody-Encoding pDNA after Intramuscular Electroporation in Mice

• المؤلفون الرئيسيون: Marie-Lynn Cuypers (مؤلف), Nick Geukens (مؤلف), Kevin Hollevoet (مؤلف), Paul Declerck (مؤلف), Maarten Dewilde (مؤلف)
• التنسيق: كتاب
• منشور في: MDPI AG, 2023-04-01T00:00:00Z.
• الموضوعات: article
• الوصول للمادة أونلاين: Connect to this object online.

DNA-based antibody therapy seeks to administer the encoding nucleotide sequence rather than the antibody protein. To further improve the in vivo monoclonal antibody (mAb) expression, a better understanding of what happens after the administration of the encoding plasmid DNA (pDNA) is required. This...