Electropharmacological effects of intracellular Ca2+ handling modulator caldaret on the heart assessed in the halothane-anesthetized dogs

• Main Authors: Atsushi Sugiyama (Author), Mihoko Hagiwara-Nagasawa (Author), Ryuichi Kambayashi (Author), Ai Goto (Author), Koki Chiba (Author), Kentaro Ando (Author), Atsuhiko T. Naito (Author), Hiroko Izumi-Nakaseko (Author)
• Format: Book
• Published: Elsevier, 2019-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We analyzed how the enhancement of net sarcoplasmic reticulum (SR) Ca2+ uptake may affect cardiac electrophysiological properties in vivo by using caldaret which can decrease SR diastolic Ca2+ leak, enhance SR Ca2+ reuptake and inhibit reverse-mode Na+/Ca2+ exchanger. Caldaret in doses of 0.5, 5 and...