Population pharmacokinetics model for escitalopram in Chinese psychiatric patients: effect of CYP2C19 and age

• Main Authors: Shujing Liu (Author), Tao Xiao (Author), Shanqing Huang (Author), Xiaolin Li (Author), Wan Kong (Author), Ye Yang (Author), Zi Zhang (Author), Xiaojia Ni (Author), Haoyang Lu (Author), Ming Zhang (Author), Dewei Shang (Author), Yuguan Wen (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: To establish a population pharmacokinetic model in Chinese psychiatric patients to characterize escitalopram pharmacokinetic profile to identify factors influencing drug exposure, and through simulation to compare the results with the established therapeutic reference range.Methods: Demog...