Advances in the discovery of cathepsin K inhibitors on bone resorption

• Үндсэн зохиолчид: Jun Lu (Зохиогч), Maolin Wang (Зохиогч), Ziyue Wang (Зохиогч), Zhongqi Fu (Зохиогч), Aiping Lu (Зохиогч), Ge Zhang (Зохиогч)
• Формат: Ном
• Хэвлэсэн: Taylor & Francis Group, 2018-01-01T00:00:00Z.
• Нөхцлүүд: article
• Онлайн хандалт: Connect to this object online.

Cathepsin K (Cat K), highly expressed in osteoclasts, is a cysteine protease member of the cathepsin lysosomal protease family and has been of increasing interest as a target of medicinal chemistry efforts for its role in bone matrix degradation. Inhibition of the Cat K enzyme reduces bone resorptio...