Advances in the discovery of cathepsin K inhibitors on bone resorption

• Main Authors: Jun Lu (Author), Maolin Wang (Author), Ziyue Wang (Author), Zhongqi Fu (Author), Aiping Lu (Author), Ge Zhang (Author)
• Format: Book
• Published: Taylor & Francis Group, 2018-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Cathepsin K (Cat K), highly expressed in osteoclasts, is a cysteine protease member of the cathepsin lysosomal protease family and has been of increasing interest as a target of medicinal chemistry efforts for its role in bone matrix degradation. Inhibition of the Cat K enzyme reduces bone resorptio...