Subantimicrobial Dose Doxycycline Worsens Chronic Arthritis-Induced Bone Microarchitectural Alterations in a Mouse Model: Role of Matrix Metalloproteinases?

• Main Authors: Ádám Horváth (Author), Bálint Botz (Author), Tamás Kiss (Author), Kata Csekő (Author), Ibolya Kiss (Author), Attila Felinger (Author), Tamara Szabados (Author), Éva Kenyeres (Author), Péter Bencsik (Author), Attila Mócsai (Author), Péter Ferdinandy (Author), Zsuzsanna Helyes (Author)
• Format: Book
• Published: Frontiers Media S.A., 2019-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Rheumatoid arthritis (RA) is a chronic inflammatory joint disease hallmarked by irreversible damage of cartilage and bone. Matrix metalloproteinases (MMPs) involved in connective tissue remodeling play an important role in this process. Numerous MMPs have been examined in humans and anim...