Pharmacokinetics, Pharmacodynamics and Antiviral Efficacy of the MEK Inhibitor Zapnometinib in Animal Models and in Humans

Pharmacokinetics, Pharmacodynamics and Antiviral Efficacy of the MEK Inhibitor Zapnometinib in Animal Models and in Humans

The mitogen-activated protein kinase (MEK) inhibitor zapnometinib is in development to treat acute viral infections like COVID-19 and influenza. While the antiviral efficacy of zapnometinib is well documented, further data on target engagement/pharmacodynamics (PD) and pharmacokinetics (PK) are need...

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Main Authors: Julia Koch-Heier (Author), Annika Schönsiegel (Author), Lara Maria Waidele (Author), Julian Volk (Author), Yvonne Füll (Author), Christian Wallasch (Author), Sebastian Canisius (Author), Michael Burnet (Author), Oliver Planz (Author)
Format: Book
Published: Frontiers Media S.A., 2022-06-01T00:00:00Z.
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