Potential natural inhibitors of xanthine oxidase and HMG-CoA reductase in cholesterol regulation: in silico analysis

• Main Authors: Rishab Marahatha (Author), Saroj Basnet (Author), Bibek Raj Bhattarai (Author), Prakriti Budhathoki (Author), Babita Aryal (Author), Bikash Adhikari (Author), Ganesh Lamichhane (Author), Darbin Kumar Poudel (Author), Niranjan Parajuli (Author)
• Format: Book
• Published: BMC, 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Hypercholesterolemia has posed a serious threat of heart diseases and stroke worldwide. Xanthine oxidase (XO), the rate-limiting enzyme in uric acid biosynthesis, is regarded as the root of reactive oxygen species (ROS) that generate atherosclerosis and cholesterol crystals. β-Hy...