A Novel Spider Toxin Inhibits Fast Inactivation of the Nav1.9 Channel by Binding to Domain III and Domain IV Voltage Sensors

• Main Authors: Shuijiao Peng (Author), Minzhi Chen (Author), Zhen Xiao (Author), Xin Xiao (Author), Sen Luo (Author), Songping Liang (Author), Xi Zhou (Author), Zhonghua Liu (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Venomous animals have evolved to produce peptide toxins that modulate the activity of voltage-gated sodium (Nav) channels. These specific modulators are powerful probes for investigating the structural and functional features of Nav channels. Here, we report the isolation and characterization of δ-t...