A Novel Spider Toxin Inhibits Fast Inactivation of the Nav1.9 Channel by Binding to Domain III and Domain IV Voltage Sensors

• Auteurs principaux: Shuijiao Peng (Auteur), Minzhi Chen (Auteur), Zhen Xiao (Auteur), Xin Xiao (Auteur), Sen Luo (Auteur), Songping Liang (Auteur), Xi Zhou (Auteur), Zhonghua Liu (Auteur)
• Format: Livre
• Publié: Frontiers Media S.A., 2021-12-01T00:00:00Z.
• Sujets: article
• Accès en ligne: Connect to this object online.

Venomous animals have evolved to produce peptide toxins that modulate the activity of voltage-gated sodium (Nav) channels. These specific modulators are powerful probes for investigating the structural and functional features of Nav channels. Here, we report the isolation and characterization of δ-t...