Integrative multi-omics identifies high risk multiple myeloma subgroup associated with significant DNA loss and dysregulated DNA repair and cell cycle pathways

• Main Authors: María Ortiz-Estévez (Author), Fadi Towfic (Author), Erin Flynt (Author), Nicholas Stong (Author), In Sock Jang (Author), Kai Wang (Author), Matthew W. B. Trotter (Author), Anjan Thakurta (Author)
• Format: Book
• Published: BMC, 2021-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Despite significant therapeutic advances in improving lives of multiple myeloma (MM) patients, it remains mostly incurable, with patients ultimately becoming refractory to therapies. MM is a genetically heterogeneous disease and therapeutic resistance is driven by a complex inter...