Integrative multi-omics identifies high risk multiple myeloma subgroup associated with significant DNA loss and dysregulated DNA repair and cell cycle pathways

• المؤلفون الرئيسيون: María Ortiz-Estévez (مؤلف), Fadi Towfic (مؤلف), Erin Flynt (مؤلف), Nicholas Stong (مؤلف), In Sock Jang (مؤلف), Kai Wang (مؤلف), Matthew W. B. Trotter (مؤلف), Anjan Thakurta (مؤلف)
• التنسيق: كتاب
• منشور في: BMC, 2021-12-01T00:00:00Z.
• الموضوعات: article
• الوصول للمادة أونلاين: Connect to this object online.

Abstract Background Despite significant therapeutic advances in improving lives of multiple myeloma (MM) patients, it remains mostly incurable, with patients ultimately becoming refractory to therapies. MM is a genetically heterogeneous disease and therapeutic resistance is driven by a complex inter...