Reduced ABCB1 Expression and Activity in the Presence of Acrylic Copolymers

• Main Authors: Ramin Mohammadzadeh (Author), Behzad Baradaran (Author), Hadi Valizadeh (Author), Bahman Yousefi (Author), Parvin Zakeri-Milani (Author)
• Format: Book
• Published: Tabriz University of Medical Sciences, 2014-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Purpose: P-glycoprotein (P-gp; ABCB1), an integral membrane protein in the apical surface of human intestinal epithelial cells, plays a crucial role in the intestinal transport and efflux leading to changes in the bioavailability of oral pharmaceutical compounds. This study was set to examine the po...