Application of Ligand- and Structure-Based Prediction Models for the Design of Alkylhydrazide-Based HDAC3 Inhibitors as Novel Anti-Cancer Compounds

• Main Authors: Emre F. Bülbül (Author), Dina Robaa (Author), Ping Sun (Author), Fereshteh Mahmoudi (Author), Jelena Melesina (Author), Matthes Zessin (Author), Mike Schutkowski (Author), Wolfgang Sippl (Author)
• Format: Book
• Published: MDPI AG, 2023-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Histone deacetylases (HDAC) represent promising epigenetic targets for several diseases including different cancer types. The HDAC inhibitors approved to date are pan-HDAC inhibitors and most show a poor selectivity profile, side effects, and in particular hydroxamic-acid-based inhibitors lack good...