Establishment of a zebrafish hematological disease model induced by 1,4-benzoquinone

• Main Authors: Ao Zhang (Author), Mei Wu (Author), Junliang Tan (Author), Ning Yu (Author), Mengchang Xu (Author), Xutong Yu (Author), Wei Liu (Author), Yiyue Zhang (Author)
• Format: Book
• Published: The Company of Biologists, 2019-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Benzene exposure is associated with various hematological disorders, in particular leukemia. The reactive metabolite of benzene, 1,4-benzoquinone (BQ), generated in bone marrow, is suggested to be a key molecule in mediating benzene-induced hematotoxicity and carcinogenicity. However, its pathogenic...