Modified Aminoglycosides Bind Nucleic Acids in High-Molecular-Weight Complexes

• Main Authors: Lanqing Ying (Author), Hongkun Zhu (Author), Marina Y. Fosso (Author), Sylvie Garneau-Tsodikova (Author), Kurt Fredrick (Author)
• Format: Book
• Published: MDPI AG, 2020-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Aminoglycosides represent a large group of antibiotics well known for their ability to target the bacterial ribosome. In studying 6”-substituted variants of the aminoglycoside tobramycin, we serendipitously found that compounds with C₁₂ or C₁₄...