Elucidation of Inverse Agonist Activity of Bilastine

• Main Authors: Hiroyuki Mizuguchi (Author), Tomoharu Wakugawa (Author), Hisato Sadakata (Author), Seiichiro Kamimura (Author), Mai Takemoto (Author), Tomomi Nakagawa (Author), Masami Yabumoto (Author), Yoshiaki Kitamura (Author), Noriaki Takeda (Author), Hiroyuki Fukui (Author)
• Format: Book
• Published: MDPI AG, 2020-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

H₁-antihistamines antagonize histamine and prevent it from binding to the histamine H₁ receptor (H1R). Some of them also act as inverse agonists, which are more potent than pure antagonists because they suppress the constitutive H1R activity. Bilastine i...