Tamoxifen is effective in the treatment of Leishmania amazonensis infections in mice.

• Main Authors: Danilo C Miguel (Author), Jenicer K U Yokoyama-Yasunaka (Author), Silvia R B Uliana (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2008-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BACKGROUND: Chemotherapy is still a critical issue in the management of leishmaniasis. Until recently, pentavalent antimonials, amphotericin B or pentamidine compounded the classical arsenal of treatment. All these drugs are toxic and have to be administered by the parenteral route. Tamoxifen has be...