A Multicomponent Protocol for the Synthesis of Highly Functionalized γ-Lactam Derivatives and Their Applications as Antiproliferative Agents

• Main Authors: Xabier del Corte (Author), Adrián López-Francés (Author), Aitor Maestro (Author), Ilia Villate-Beitia (Author), Myriam Sainz-Ramos (Author), Edorta Martínez de Marigorta (Author), José Luis Pedraz (Author), Francisco Palacios (Author), Javier Vicario (Author)
• Format: Book
• Published: MDPI AG, 2021-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

An efficient synthetic methodology for the preparation of 3-amino 1,5-dihydro-2<i>H</i>-pyrrol-2-ones through a multicomponent reaction of amines, aldehydes, and pyruvate derivatives is reported. In addition, the densely substituted lactam substrates show in vitro cytotoxicity, inhibitin...