Metabolic insights from a GHSR-A203E mutant mouse model

• Main Authors: Lola J. Torz (Author), Sherri Osborne-Lawrence (Author), Juan Rodriguez (Author), Zhenyan He (Author), María Paula Cornejo (Author), Emilio Román Mustafá (Author), Chunyu Jin (Author), Natalia Petersen (Author), Morten A. Hedegaard (Author), Maja Nybo (Author), Valentina Martínez Damonte (Author), Nathan P. Metzger (Author), Bharath K. Mani (Author), Kevin W. Williams (Author), Jesica Raingo (Author), Mario Perello (Author), Birgitte Holst (Author), Jeffrey M. Zigman (Author)
• Format: Book
• Published: Elsevier, 2020-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Binding of ghrelin to its receptor, growth hormone secretagogue receptor (GHSR), stimulates GH release, induces eating, and increases blood glucose. These processes may also be influenced by constitutive (ghrelin-independent) GHSR activity, as suggested by findings in short people with na...