Toward the Identification of Natural Antiviral Drug Candidates against Merkel Cell Polyomavirus: Computational Drug Design Approaches

• Main Authors: Amer H. Asseri (Author), Md. Jahidul Alam (Author), Faisal Alzahrani (Author), Ahmed Khames (Author), Mohammad Turhan Pathan (Author), Mohammed A. S. Abourehab (Author), Salman Hosawi (Author), Rubaiat Ahmed (Author), Sifat Ara Sultana (Author), Nazia Fairooz Alam (Author), Nafee-Ul Alam (Author), Rahat Alam (Author), Abdus Samad (Author), Sushil Pokhrel (Author), Jin Kyu Kim (Author), Foysal Ahammad (Author), Bonglee Kim (Author), Shing Cheng Tan (Author)
• Format: Book
• Published: MDPI AG, 2022-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Merkel cell carcinoma (MCC) is a rare form of aggressive skin cancer mainly caused by Merkel cell polyomavirus (MCPyV). Most MCC tumors express MCPyV large T (LT) antigens and play an important role in the growth-promoting activities of oncoproteins. Truncated LT promotes tumorigenicity as well as h...