Biotin-Labelled Clavulanic Acid to Identify Proteins Target for Haptenation in Serum: Implications in Allergy Studies

• Main Authors: Ángela Martín-Serrano (Author), Juan M. Gonzalez-Morena (Author), Nekane Barbero (Author), Adriana Ariza (Author), Francisco J. Sánchez Gómez (Author), Ezequiel Pérez-Inestrosa (Author), Dolores Pérez-Sala (Author), Maria J. Torres (Author), María I. Montañez (Author)
• Format: Book
• Published: Frontiers Media S.A., 2020-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Clavulanic acid (CLV) and amoxicillin, frequently administered in combination, can be independently involved in allergic reactions. Protein haptenation with β-lactams is considered necessary to activate the immune system. The aim of this study was to assess the suitability of biotinylated analogues...