Loss of vhl in the zebrafish pronephros recapitulates early stages of human clear cell renal cell carcinoma

Loss of vhl in the zebrafish pronephros recapitulates early stages of human clear cell renal cell carcinoma

Patients with von Hippel-Lindau (VHL) disease harbor a germline mutation in the VHL gene leading to the development of several tumor types including clear cell renal cell carcinoma (ccRCC). In addition, the VHL gene is inactivated in over 90% of sporadic ccRCC cases. 'Clear cell' tumors co...

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Main Authors: Haley R. Noonan (Author), Ana M. Metelo (Author), Caramai N. Kamei (Author), Randall T. Peterson (Author), Iain A. Drummond (Author), Othon Iliopoulos (Author)
Format: Book
Published: The Company of Biologists, 2016-08-01T00:00:00Z.
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