Aptamer-Driven Toxin Gene Delivery in U87 Model Glioblastoma Cells

Aptamer-Driven Toxin Gene Delivery in U87 Model Glioblastoma Cells

A novel suicide gene therapy approach was tested in U87 MG glioblastoma multiforme cells. A 26nt G-rich double-stranded DNA aptamer (AS1411) was integrated into a vector at the 5' of a mammalian codon-optimized saporin gene, under CMV promoter. With this plasmid termed "APTSAP", the g...

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Main Authors: Luana di Leandro (Author), Francesco Giansanti (Author), Sabrina Mei (Author), Sara Ponziani (Author), Martina Colasante (Author), Matteo Ardini (Author), Francesco Angelucci (Author), Giuseppina Pitari (Author), Michele d'Angelo (Author), Annamaria Cimini (Author), Maria Serena Fabbrini (Author), Rodolfo Ippoliti (Author)
Format: Book
Published: Frontiers Media S.A., 2021-04-01T00:00:00Z.
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3rd Floor Main Library

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