Aptamer-Driven Toxin Gene Delivery in U87 Model Glioblastoma Cells

• 主要な著者: Luana di Leandro (著者), Francesco Giansanti (著者), Sabrina Mei (著者), Sara Ponziani (著者), Martina Colasante (著者), Matteo Ardini (著者), Francesco Angelucci (著者), Giuseppina Pitari (著者), Michele d'Angelo (著者), Annamaria Cimini (著者), Maria Serena Fabbrini (著者), Rodolfo Ippoliti (著者)
• フォーマット: 図書
• 出版事項: Frontiers Media S.A., 2021-04-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

A novel suicide gene therapy approach was tested in U87 MG glioblastoma multiforme cells. A 26nt G-rich double-stranded DNA aptamer (AS1411) was integrated into a vector at the 5' of a mammalian codon-optimized saporin gene, under CMV promoter. With this plasmid termed "APTSAP", the g...