Aptamer-Driven Toxin Gene Delivery in U87 Model Glioblastoma Cells
A novel suicide gene therapy approach was tested in U87 MG glioblastoma multiforme cells. A 26nt G-rich double-stranded DNA aptamer (AS1411) was integrated into a vector at the 5' of a mammalian codon-optimized saporin gene, under CMV promoter. With this plasmid termed "APTSAP", the g...
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| Main Authors: | , , , , , , , , , , , |
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| Format: | Book |
| Published: |
Frontiers Media S.A.,
2021-04-01T00:00:00Z.
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