Aromatase-Inhibitor-Induced Musculoskeletal Inflammation Is Observed Independent of Oophorectomy in a Novel Mouse Model

• Main Authors: Nicholas A. Young (Author), Jeffrey Hampton (Author), Juhi Sharma (Author), Kyle Jablonski (Author), Courtney DeVries (Author), Anna Bratasz (Author), Lai-Chu Wu (Author), Maryam Lustberg (Author), Raquel Reinbolt (Author), Wael N. Jarjour (Author)
• Format: Book
• Published: MDPI AG, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Aromatase Inhibitors (AIs) block estrogen production and improve survival in patients with hormone-receptor-positive breast cancer. However, half of patients develop aromatase-inhibitor-induced arthralgia (AIIA), which is characterized by inflammation of the joints and the surrounding musculoskeleta...