Fine Mapping of the Interaction between C4b-Binding Protein and Outer Membrane Proteins LigA and LigB of Pathogenic Leptospira interrogans.

• Main Authors: Leandro C D Breda (Author), Ching-Lin Hsieh (Author), Mónica M Castiblanco Valencia (Author), Ludmila B da Silva (Author), Angela S Barbosa (Author), Anna M Blom (Author), Yung-Fu Chang (Author), Lourdes Isaac (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2015-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The complement system consists of more than 40 proteins that participate in the inflammatory response and in pathogen killing. Complement inhibitors are necessary to avoid the excessive consumption and activation of this system on host cells. Leptospirosis is a worldwide zoonosis caused by spirochet...