Population PK/PD modeling of low‐density lipoprotein cholesterol response in hypercholesterolemic participants following administration of bococizumab, a potent anti‐PCSK9 monoclonal antibody

Population PK/PD modeling of low‐density lipoprotein cholesterol response in hypercholesterolemic participants following administration of bococizumab, a potent anti‐PCSK9 monoclonal antibody

Abstract We sought to characterize the population pharmacokinetic/pharmacodynamic (PK/PD) relationship of bococizumab (RN316/PF‐04950615), a humanized IgG2Δa monoclonal antibody that binds to secreted human proprotein convertase subtilisin kexin type 9 (PCSK9), using data derived from 16 phase I, II...

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Main Authors: Ellen Q. Wang (Author), Nitin Kaila (Author), David Plowchalk (Author), Leonid Gibiansky (Author), Carla Yunis (Author), Kevin Sweeney (Author)
Format: Book
Published: Wiley, 2023-12-01T00:00:00Z.
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