Population PK/PD modeling of low‐density lipoprotein cholesterol response in hypercholesterolemic participants following administration of bococizumab, a potent anti‐PCSK9 monoclonal antibody

• मुख्य लेखकों: Ellen Q. Wang (लेखक), Nitin Kaila (लेखक), David Plowchalk (लेखक), Leonid Gibiansky (लेखक), Carla Yunis (लेखक), Kevin Sweeney (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Wiley, 2023-12-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Abstract We sought to characterize the population pharmacokinetic/pharmacodynamic (PK/PD) relationship of bococizumab (RN316/PF‐04950615), a humanized IgG2Δa monoclonal antibody that binds to secreted human proprotein convertase subtilisin kexin type 9 (PCSK9), using data derived from 16 phase I, II...