13-(2-Methylbenzyl) Berberine Is a More Potent Inhibitor of MexXY-Dependent Aminoglycoside Resistance than Berberine

• Main Authors: Kenta Kotani (Author), Mio Matsumura (Author), Yuji Morita (Author), Junko Tomida (Author), Ryo Kutsuna (Author), Kunihiko Nishino (Author), Shuji Yasuike (Author), Yoshiaki Kawamura (Author)
• Format: Book
• Published: MDPI AG, 2019-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We previously showed that berberine attenuates MexXY efflux-dependent aminoglycoside resistance in <i>Pseudomonas aeruginosa</i>. Here, we aimed to synthesize berberine derivatives with higher MexXY inhibitory activities. We synthesized 11 berberine derivatives, of which 13-(2-methylbenz...