27-Hydroxycholesterol/liver X receptor/apolipoprotein E mediates zearalenone-induced intestinal immunosuppression: A key target potentially linking zearalenone and cancer

• Main Authors: Haonan Ruan (Author), Jing Zhang (Author), Yunyun Wang (Author), Ying Huang (Author), Jiashuo Wu (Author), Chunjiao He (Author), Tongwei Ke (Author), Jiaoyang Luo (Author), Meihua Yang (Author)
• Format: Book
• Published: Elsevier, 2024-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Zearalenone (ZEN) is a mycotoxin that extensively contaminates food and feed, posing a significant threat to public health. However, the mechanisms behind ZEN-induced intestinal immunotoxicity remain unclear. In this study, Sprague-Dawley (SD) rats were exposed to ZEN at a dosage of 5 mg/kg/day b.w....