27-Hydroxycholesterol/liver X receptor/apolipoprotein E mediates zearalenone-induced intestinal immunosuppression: A key target potentially linking zearalenone and cancer
Zearalenone (ZEN) is a mycotoxin that extensively contaminates food and feed, posing a significant threat to public health. However, the mechanisms behind ZEN-induced intestinal immunotoxicity remain unclear. In this study, Sprague-Dawley (SD) rats were exposed to ZEN at a dosage of 5 mg/kg/day b.w....
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Elsevier,
2024-03-01T00:00:00Z.
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| 001 | doaj_e3b0bc20f7bc4a3aa10f4f80e3f06e6e | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Haonan Ruan |e author |
| 700 | 1 | 0 | |a Jing Zhang |e author |
| 700 | 1 | 0 | |a Yunyun Wang |e author |
| 700 | 1 | 0 | |a Ying Huang |e author |
| 700 | 1 | 0 | |a Jiashuo Wu |e author |
| 700 | 1 | 0 | |a Chunjiao He |e author |
| 700 | 1 | 0 | |a Tongwei Ke |e author |
| 700 | 1 | 0 | |a Jiaoyang Luo |e author |
| 700 | 1 | 0 | |a Meihua Yang |e author |
| 245 | 0 | 0 | |a 27-Hydroxycholesterol/liver X receptor/apolipoprotein E mediates zearalenone-induced intestinal immunosuppression: A key target potentially linking zearalenone and cancer |
| 260 | |b Elsevier, |c 2024-03-01T00:00:00Z. | ||
| 500 | |a 2095-1779 | ||
| 500 | |a 10.1016/j.jpha.2023.08.002 | ||
| 520 | |a Zearalenone (ZEN) is a mycotoxin that extensively contaminates food and feed, posing a significant threat to public health. However, the mechanisms behind ZEN-induced intestinal immunotoxicity remain unclear. In this study, Sprague-Dawley (SD) rats were exposed to ZEN at a dosage of 5 mg/kg/day b.w. for a duration of 14 days. The results demonstrated that ZEN exposure led to notable pathological alterations and immunosuppression within the intestine. Furthermore, ZEN exposure caused a significant reduction in the levels of apolipoprotein E (ApoE) and liver X receptor (LXR) (P < 0.05). Conversely, it upregulated the levels of myeloid-derived suppressor cells (MDSCs) markers (P < 0.05) and decreased the presence of 27-hydroxycholesterol (27-HC) in the intestine (P < 0.05). It was observed that ApoE or LXR agonists were able to mitigate the immunosuppressive effects induced by ZEN. Additionally, a bioinformatics analysis highlighted that the downregulation of ApoE might elevate the susceptibility to colorectal, breast, and lung cancers. These findings underscore the crucial role of the 27-HC/LXR/ApoE axis disruption in ZEN-induced MDSCs proliferation and subsequent inhibition of T lymphocyte activation within the rat intestine. Notably, ApoE may emerge as a pivotal target linking ZEN exposure to cancer development. | ||
| 546 | |a EN | ||
| 690 | |a Zearalenone | ||
| 690 | |a Intestinal immunosuppression | ||
| 690 | |a Apolipoprotein E | ||
| 690 | |a Bioinformatics analysis | ||
| 690 | |a Cancer | ||
| 690 | |a Therapeutics. Pharmacology | ||
| 690 | |a RM1-950 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Journal of Pharmaceutical Analysis, Vol 14, Iss 3, Pp 371-388 (2024) | |
| 787 | 0 | |n http://www.sciencedirect.com/science/article/pii/S2095177923001880 | |
| 787 | 0 | |n https://doaj.org/toc/2095-1779 | |
| 856 | 4 | 1 | |u https://doaj.org/article/e3b0bc20f7bc4a3aa10f4f80e3f06e6e |z Connect to this object online. |