A combined linkage, microarray and exome analysis suggests MAP3K11 as a candidate gene for left ventricular hypertrophy

• Main Authors: Claudia Tamar Silva (Author), Irina V. Zorkoltseva (Author), Maartje N. Niemeijer (Author), Marten E. van den Berg (Author), Najaf Amin (Author), Ayşe Demirkan (Author), Elisa van Leeuwen (Author), Adriana I. Iglesias (Author), Laura B. Piñeros-Hernández (Author), Carlos M. Restrepo (Author), Jan A. Kors (Author), Anatoly V. Kirichenko (Author), Rob Willemsen (Author), Ben A. Oostra (Author), Bruno H. Stricker (Author), André G. Uitterlinden (Author), Tatiana I. Axenovich (Author), Cornelia M. van Duijn (Author), Aaron Isaacs (Author)
• Format: Book
• Published: BMC, 2018-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Electrocardiographic measures of left ventricular hypertrophy (LVH) are used as predictors of cardiovascular risk. We combined linkage and association analyses to discover novel rare genetic variants involved in three such measures and two principal components derived from them....