Long-term effects of mepolizumab in patients with severe eosinophilic asthma: a 6-year real-life experience

• Main Authors: Anna Agnese Stanziola (Author), Claudio Candia (Author), Gerardo Nazzaro (Author), Antonio Caso (Author), Claudia Merola (Author), Lorena Gallotti (Author), Mauro Maniscalco (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BackgroundSevere eosinophilic asthma (SEA) is often linked to a dysregulation in the Interleukin-(IL)-5 axis. Mepolizumab, a humanized monoclonal antibody, reduces eosinophils by directly binging to IL-5, potentially restoring homeostatic eosinophil biology, with a significant impact on quality of l...