Mesenchymal Stem Cell Therapy for Doxorubicin-Induced Cardiomyopathy: Potential Mechanisms, Governing Factors, and Implications of the Heart Stem Cell Debate

• Main Authors: Abdelrahman Ibrahim Abushouk (Author), Amr Muhammad Abdo Salem (Author), Anas Saad (Author), Ahmed M. Afifi (Author), Abdelrahman Yousry Afify (Author), Hesham Afify (Author), Hazem S.E. Salem (Author), Esraa Ghanem (Author), Mohamed M. Abdel-Daim (Author)
• Format: Book
• Published: Frontiers Media S.A., 2019-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Over the past decades, researchers have reported several mechanisms for doxorubicin (DOX)-induced cardiomyopathy, including oxidative stress, inflammation, and apoptosis. Another mechanism that has been suggested is that DOX interferes with the cell cycle and induces oxidative stress in C-kit+ cells...