IL-6 blockade in systemic juvenile idiopathic arthritis - achievement of inactive disease and remission (data from the German AID-registry)

• Main Authors: M. Bielak (Author), E. Husmann (Author), N. Weyandt (Author), J.-P. Haas (Author), B. Hügle (Author), G. Horneff (Author), U. Neudorf (Author), T. Lutz (Author), E. Lilienthal (Author), T. Kallinich (Author), K. Tenbrock (Author), R. Berendes (Author), T. Niehues (Author), H. Wittkowski (Author), E. Weißbarth-Riedel (Author), G. Heubner (Author), P. Oommen (Author), J. Klotsche (Author), Dirk Foell (Author), E. Lainka (Author)
• Format: Book
• Published: BMC, 2018-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Systemic juvenile idiopathic arthritis (sJIA) is a complex disease with an autoinflammatory component of unknown etiology related to the innate immune system. A major role in the pathogenesis has been ascribed to proinflammatory cytokines like interleukin-6 (IL-6), and effective...