A novel trypsin of Trichinella spiralis mediates larval invasion of gut epithelium via binding to PAR2 and activating ERK1/2 pathway.

• Main Authors: Lu Lu Han (Author), Qi Qi Lu (Author), Wen Wen Zheng (Author), Yang Li Li (Author), Yan Yan Song (Author), Xin Zhuo Zhang (Author), Shao Rong Long (Author), Ruo Dan Liu (Author), Zhong Quan Wang (Author), Jing Cui (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2024-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

<h4>Background</h4>Proteases secreted by Trichinella spiralis intestinal infective larvae (IIL) play an important role in larval invasion and pathogenesis. However, the mechanism through which proteases mediate larval invasion of intestinal epithelial cells (IECs) remains unclear. A nove...