Novel Black Seed Polysaccharide Extract-g-Poly (Acrylate) pH-Responsive Hydrogel Nanocomposites for Safe Oral Insulin Delivery: Development, In Vitro, In Vivo and Toxicological Evaluation

• Ngā kaituhi matua: Farya Shabir (Author), Asif Mahmood (Author), Nadiah Zafar (Author), Muhammad Zaman (Author), Rai Muhammad Sarfraz (Author), Hira Ijaz (Author)
• Hōputu: Pukapuka
• I whakaputaina: MDPI AG, 2022-12-01T00:00:00Z.
• Ngā marau: article
• Urunga tuihono: Connect to this object online.

Oral delivery of insulin has always been a challenging task due to harsh gut environment involving variable pH and peptidase actions. Currently, no Food and Drug Administration (FDA) approved oral insulin formulation is commercially available, only intravenous (IV) or subcutaneous (SC) routes. There...