Minocycline Ameliorates Depressive-Like Behavior and Demyelination Induced by Transient Global Cerebral Ischemia by Inhibiting Microglial Activation

• Main Authors: Bingying Du (Author), Hailong Li (Author), Huiwen Zheng (Author), Cunxiu Fan (Author), Meng Liang (Author), Yongjie Lian (Author), Zelan Wei (Author), Yanbo Zhang (Author), Xiaoying Bi (Author)
• Format: Book
• Published: Frontiers Media S.A., 2019-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Global cerebral ischemia (GCI) commonly occurs in the elderly. Subcortical white matter lesions and oligodendrocyte (OLG) loss caused by cerebral ischemia have been implicated in the development of post-ischemic depression and cognitive impairment. OLGs are necessary for axonal myelination; the disr...