Functional effects of drugs and toxins interacting with NaV1.4

• Main Authors: Xinyi Zou (Author), Zixuan Zhang (Author), Hui Lu (Author), Wei Zhao (Author), Lanying Pan (Author), Yuan Chen (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

NaV1.4 is a voltage-gated sodium channel subtype that is predominantly expressed in skeletal muscle cells. It is essential for producing action potentials and stimulating muscle contraction, and mutations in NaV1.4 can cause various muscle disorders. The discovery of the cryo-EM structure of NaV1.4...