Dilution of oral D3‐Creatine to measure creatine pool size and estimate skeletal muscle mass: development of a correction algorithm

• Main Authors: Mahalakshmi Shankaran (Author), Gregg Czerwieniec (Author), Chancy Fessler (Author), Po‐yin Anne Wong (Author), Salena Killion (Author), Scott M. Turner (Author), Marc K. Hellerstein (Author), William J. Evans (Author)
• Format: Book
• Published: Wiley, 2018-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Muscle mass can be measured directly in vivo by isotope dilution, using Creatine‐(methyl‐d3) monohydrate (D3‐Cr) by mouth followed by measurement of the steady‐state enrichment of D3‐creatinine (D3‐Crn) in urine. Isotope dilution methods require knowledge of the amount of tracer...