Identification of small molecules that mitigate vincristine‐induced neurotoxicity while sensitizing leukemia cells to vincristine

• Main Authors: Barthelemy Diouf (Author), Claudia Wing (Author), John C. Panetta (Author), Donnie Eddins (Author), Wenwei Lin (Author), Wenjian Yang (Author), Yiping Fan (Author), Deqing Pei (Author), Cheng Cheng (Author), Shannon M. Delaney (Author), Wei Zhang (Author), Erik J. Bonten (Author), Kristine R. Crews (Author), Steven W. Paugh (Author), Lie Li (Author), Burgess B. Freeman 3rd (Author), Robert J. Autry (Author), Jordan A. Beard (Author), Daniel C. Ferguson (Author), Laura J. Janke (Author), Kirsten K. Ness (Author), Taosheng Chen (Author), Stanislav S. Zakharenko (Author), Sima Jeha (Author), Ching‐Hon Pui (Author), Mary V. Relling (Author), M. Eileen Dolan (Author), William E. Evans (Author)
• Format: Book
• Published: Wiley, 2021-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Vincristine (VCR) is one of the most widely prescribed medications for treating solid tumors and acute lymphoblastic leukemia (ALL) in children and adults. However, its major dose‐limiting toxicity is peripheral neuropathy that can disrupt curative therapy. Peripheral neuropathy can also pe...